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The McCarty Research group makes a splash in Seattle at the 43rd annual ASBMB.

With a rich offering of multi-discipline presentations, this year was a treasure trove of exploration and thought explosion. We learned about lipids, pathways, and artificial neural networks. The RFdiffusion method with its use of noise to build proteins around a ligand was introduced by none other than Dr. David Baker himself. Our networks were bolstered, and inspiration instilled. We are looking forward to next year in San Antonio where we will be sharing our most recent results.


The McCarty Research Group's three master's students from left to right;

Kyle Whitham, Kayla Croney, & David Cummins checking into the ASBMB 2023


We were not the only Vikings in the Emerald City as we ran into members of the WWU biochemistry research cohort. Getting to hear the results of their hard work was amazing.

Listening in on fellow WWU researchers from the Dr. Amacher lab Katy LIndblom and Elise Tahti's discoveries on the specificity of Sortase A.


The "Discover" in Discover ASMBMB 2023 was apparent as we found our flock of computational chemists. Ideas were flown about and we felt for the first time that someone actually understood us!

Meeting a fellow computational biochemist, Babak Sanei from Los Angeles, CA leads to opportunity for collaboration in the future.


As the last day's dust settles, our poster presentation drew a crowd of like-minded computational inquirers and novices as well. The Sortase B enzyme was well explained and the methods of analysis shown in great detail.

David Cummins & Kyle Whitham show their preliminary work on the molecular dynamics of chimeric loop swapped Sortase B enzymes and exploration of the catalytic mechanism via quantum mechanical studies.


In prime poster position is Kayla Croney's detailing of metadynamics and the way she used volume-based collected variables to overcome reaction barriers in product unbinding.

Kayla Croney presenting her findings via volume-based metadynamics of the yeast Cytosine Deaminase.


A mid day stroll down Pike St. brings us to the Pike's Place Market in downtown Seattle, WA.

Did you really travel to Seattle if you didn't see flying salmon at the Pike's Place Market?

From top left to bottom right: Abigail Andersen, Frederick Longshore-Neate, David Cummins, Jeanine Amacher, Kyle Whitham, Kayla Croney, Dr. Sierra Cullati, Hanna Kodama, & Elise Tahti.


And for the cherry on top, we ended the night with a reunion of lab mates at a hot-pot style Chinese restaurant. The food was to die for, and the fun we had reminiscing was unbeatable.

As the hot-pot style soothed our stomachs, meeting up with McCarty Research Group alumni Alden Harris and Isabelle Kim filled our hearts with sincere comradery.


We thank everyone we met, and all the people who put together the conference as well as the speakers and presenters. It was a formidable experience, and we would not miss out on next year in sunny San Antonio March 23 to the 26th 2024.


Updated: Apr 20, 2023

Welcome to the Science Blog!


Taking inspiration from interesting biological questions arising on the bench-top, we seek to observe in silico simulations of enzymatic proteins to uncover micro-scale interactions of their mechanisms and molecular dynamics. The interactions as substrates go between reaction and product states are uncovered through diverting into a quantum force field. We seek to understand the action of ligand binding and unbinding through careful observation of collected variables through metadynamics.



Also in the group but not pictured is Amir Shahzad. Join along as we provide updates on upcoming published works on molecular and metadynamic processes in biochemistry, conferences we attend in the biomedical and molecular biology field, and presentations of findings and upcoming experiments.


Life in Western Washington University


Being a biochemists is challenging but fun, and being a computational biochemist is even funner because the challenges are multi-dimensional. Nestled in the foothills of the Rocky Mountains that reach out to the sea, here in Bellingham WA when we are not busy studying a new biological system in silico we like to hike the steep terrain, mountain bike the ancient paths, ski through pillows of fresh powdery snow, kayak the open waters, and sail the briny seas. Not only are we avid mini golf enthusiasts, we enjoy games such as pickle-ball, corn-hole, golfing, and the occasional rainy day board game. The importance of community is not lost on us, as we actively participate in sustainability.

Till Next Time we Meet

If you were an enzyme what would you catalyze?

I invite you to write a comment down below to introduce yourself and your interests. We love to meet and hear from other computational research groups and experimental collaborators. In science the key to perpetual motion of thought is being open to facilitating any conversation.

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